Cocaine is intertwined with the social and scientific fabric in deeper ways than most people realize. Join us to learn about 1) current data on cocaine use, 2) the history and discovery of cocaine, 3) the first historical total synthesis of cocaine by Richard Wilstätter, and 4) other developments in the (bio)chemical synthesis (Robinson, Noyori). Note that we do not discuss biological origins, isolation, or other aspects in detail.

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No information on this channel is intended to be a substitute for professional medical advice, diagnosis or treatment. Always seek the advice of your physician or other qualified health care professional with any questions you may have regarding a health problem or treatment and before undertaking a new health care regimen, and never disregard seek professional medical advice or never delay seeking it because of information on Youtube. .

Key references:
– UNODC, World Cocaine Report 2023 (United Nations publications, 2023)
– Estimation of the incidence of cocaine use and mortality using musical lyrics about cocaine | npj Digital medicine 2021, 4, 100
– Cocaine: an updated overview of chemistry, detection, biokinetics and pharmacotoxicological aspects, including patterns of abuse | Toxins 2022, 14, 278
– DARK Classics in chemical neuroscience: Cocaine | ACS Chem Neurosci2018, 9, 2358
– Cocaine Use Disorder (CUD): Current Clinical Perspectives | Rehabilitation for sexual abuse. 2022; 1:25 p.m.
– Use of braunen chlorine product installation on Elaylgas | Justus Liebigs Annalen 1860, 113, 288 (not 257 as in the video, sorry!)
– Synthesis of Tropidines | Ber. Dsch. Chemical. Ges. 1901, 34, 129
– Uber die Umwandlung von Tropidin à Tropin | Ber. Dsch. Chemical. Ges 1902, 35, 1870
– Management of Tropidin in Tropin | Ber. Dsch. Chemical. Ges 1902, 35, 2295
– Synthesis of active Coniine | Ber. Dsch. Chemical. Ges 1886, 19, 2578
– Richard Willstätter and the 1915 Nobel Prize in Chemistry | Angew. Chemical. Int. Ed. 2015, 54, 11910
– A synthesis of tropinone | J.Chem. Soc., Trans., 1917, 111, 762
– New general synthesis of tropane alkaloids | JACS 1974, 96, 3336
– Elucidation of tropane alkaloid biosynthesis in Erythroxylum coca using a microbial pathway discovery platform | PNAS 2022, 119, e2215372119
– Discovery and engineering of the cocaine biosynthesis pathway | JACS 2022, 144, 22000 (and not 21809)

Some recommended books on organic synthesis:
-Clayden, Greeves, Warren; Organic Chemistry (basic knowledge of organic chemistry)
-Wyatt, Warren; Organic synthesis: the disconnection approach (excellent introduction to retrosynthesis)
– Kurti, Czako; Strategic applications of named reactions in organic synthesis (comprehensive toolbox of functional group reactions and applications thereof with common conditions)
-Nicolaou; Total Synthesis Classics 1-3 (The Ultimate Total Synthesis Trilogy)
-Nicolaou; Molecules that changed the world (the most important molecules in the world and their impact on daily life)
– Carreira, Kvaerno; Classics of stereoselective synthesis (compilation of revolutionary methods of stereoselective synthesis and application to the synthesis of stereochemically complex structures)

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